Syrian Hamster Sars Cov 2

Immunohistochemistry demonstrated viral antigens in nasal mucosa bronchial epithelial cells and in.

Syrian hamster sars cov 2. Each system contained 2 cages left and right separated by a polyvinyl chloride air porous partition. Simulation of the clinical and pathological manifestations of coronavirus disease 2019 covid 19 in golden syrian hamster model. A sars cov 2 specific human neutralizing mab cc12 1 isolated from natural infection was administered at a starting dose of 2 mg per animal average. An electrically powered fan was.

16 5 mg kg and subsequent serial fourfold dilutions. In addition microcomputed tomographic imaging revealed severe lung injury that shared characteristics with sars cov 2 infected human lung including. Effective vaccines and therapeutics for sars cov 2 induced disease coronavirus disease 2019 covid 19 are urgently needed. B enlarged view of the closed systems used in the noncontact transmission studies.

Maximal clinical signs of rapid breathing weight loss histopathological changes from the initial exudative phase of diffuse alveolar damage with extensive apoptosis to the later proliferative phase of tissue repair airway and intestinal involvement with virus nucleocapsid protein expression high lung viral load and spleen. The investigators infected two different age groups of syrian hamsters 1 month old and 7 8 month old with either a high dose or low dose of sars cov 2 or with pbs mock infection via. Sars cov 2 isolates replicated efficiently in the lungs of hamsters causing severe pathological lung lesions following intranasal infection. A the closed systems housing the hamsters were placed in the isolator in a biosafety level 3 laboratory.

After sars cov 2 infection the hamsters show rapid breathing weight loss and diffuse alveolar damage with extensive apoptosis. We found that sars cov 2 isolates replicate efficiently in the lungs of syrian hamsters and cause severe pathological lesions in the lungs of these animals similar to commonly reported imaging. Maximal clinical signs of rapid breathing weight loss histopathological changes from the initial exudative phase of diffuse alveolar damage with extensive apoptosis to the later proliferative phase of tissue repair airway and intestinal involvement with virus nucleocapsid protein expression high lung viral load and. Implications for disease pathogenesis and transmissibility.

Noncontact transmission of sars cov 2 in the syrian hamster model. Here we assessed the replicative ability and pathogenesis of sars cov 2 isolates in syrian hamsters. Control animals received 2 mg of den3. Each group of six.

The syrian hamster could be consistently infected by sars cov 2. 5 a potent sars cov 2 rbd specific neutralizing mab protects against weight loss and lung viral replication in syrian hamsters. The pathogenicity and transmissibility of sars cov 2 in golden syrian hamsters resemble features of covid 19 in human patients suggesting that these hamsters could be used to model this disease.